Pii: S0197-4580(01)00266-4
نویسندگان
چکیده
Cardiovascular Division, Department of Medicine, and Margret and H.A. Rey Laboratory for Nonlinear Dynamics in Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, USA Gerontology Division, Department of Medicine, Beth Israel Deaconess Medical Center; Division on Aging, Harvard Medical School; Research and Training Institute, Hebrew Rehabilitation Center for the Aged, Boston, MA, USA
منابع مشابه
Pii: S0197-4580(00)00250-5
In the course of normal aging from about age 20 to 100, the population density of neocortical synapses declines toward, but not reaching, the level found in Alzheimer disease. A deficiency of synapses at birth or due to inadequate childhood education would theoretically cause the synaptic slope to reach the Alzheimer level early. The normal slope would cross into that dementia range at about ag...
متن کاملPii: S0197-4580(01)00315-3
Pre-existing trauma to basal forebrain corticopetal cholinergic neurons has been hypothesized to render this system vulnerable to age-related processes. The present longitudinal study assessed the interactions between the effects of partial cortical cholinergic deafferentation and aging on sustained attention performance. After pre-surgical training, animals were given sham-surgery or bilateral...
متن کاملPii: S0197-4580(01)00250-0
We investigated whether object recognition memory is modulated by estrogen in young (5 month) and aged (24 month) female C57Bl/6J mice, and if cholinergic muscarinic receptors might contribute to this response. Mice that were ovariectomized, or ovariectomized plus estradiol-treated three weeks before behavioral testing or quantitative autoradiography were compared to intact mice. Memory for a p...
متن کاملPii: S0197-4580(00)00131-7
In the present study, we sought to determine whether low-grade, chronic vascular insufficiency induced in a rodent model of chronic cerebrohypoperfusion is sufficient, in and of itself, to trigger cleavage of the amyloid precursor protein (APP) into bA-sized fragments. We report that chronic two vessel occlusion (2VO) results in progressive accumulation of bA peptides detected by Western analys...
متن کاملPii: S0197-4580(01)00237-8
Sex differences in neurochemical markers that correlate with behavior in aging mice NEUROBIOL AGING. We examined whether the enzymatic activities of choline acetyltransferase (ChAT) and glutamic acid decarboxylase (GAD) were altered similarly with age in male and female mice, and whether these changes were correlated with age-related alterations in memory and anxiety. ChAT and GAD activities we...
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